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hM4Di-mediated inhibition of the PL-DRN pathway prevents the prophylactic effect of prior ketamine on JSE. Rats previously injected with hM4Di or mCherry targeted to the PL-DRN pathway received a single injection of saline or ketamine one week before IS or HC. JSE was assessed 24 h after IS or HC. Tukey’s post hoc method: **p < 0.01. Bars represent group mean ± SEM. Symbols represent mean social exploration for rats that received HC or IS during diestrus, proestrus, or estrus.
