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. 2018 Mar 5;217(3):1113–1128. doi: 10.1083/jcb.201709064

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© 2018 Urbina et al.

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Figure 5. — Different domains of TRIM9 modulate specific parameters of exocytosis in neurites. (A) Domain organization of mouse TRIM9 (top) and domain mutants that lack the ubiquitin ligase containing RING domain (TRIM9ΔRING), the DCC binding SPRY domain (TRIM9ΔSPRY), or the CC motif (TRIM9ΔCC), which mediates TRIM9 multimerization and interaction with SNAP25. (B–D) Box and whisker plots of frequency of VAMP2-pHluorin–mediated exocytosis across basal plasma membrane of neurons (box shows median ± IQR, whiskers reach minimum and maximum values within 1.5 times the IQR). (B), neurites (C), or soma (D) in Trim9^+/+ and Trim9^−/− neurons expressing the indicated TRIM9 domain mutants (n = 17 for each condition; *, P < 0.05; **, P < 0.005). See Fig. S5.