Table 1. Ratio interaction of groups treated with RBV, melittin, apamin, BBM.
| Component (concentration) | Group | Interval | F (p-value) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 5 | Day 7 | Day 9 | Day 11 | Day 13 | Time | Group | Time×group | ||
| RBV (0.1 mg/100 µl) | Ex. | 1.000±0.000 | 1.114±0.097 | 1.146±0.094 | 1.156±0.158 | 1.153±0.089 | 1.093±0.101 | 1.031±0.028 | 6.834 (0.000)* | 5.711 (0.054) | 2.050 (0.084) |
| Co. | 1.000±0.000 | 1.369±0.269 | 1.326±0.059 | 1.241±0.093 | 1.131±0.050 | 1.117±0.072 | 1.045±0.036 | ||||
| RBV (10 mg/100 µl) | Ex. | 1.000±0.000 | 1.152±0.050 | 1.122±0.046 | 1.235±0.114 | 1.149±0.053 | 1.102±0.070 | 1.165±0.157 | 7.906 (0.005)* | 3.834 (0.098) | 4.849 (0.026)* |
| Co. | 1.000±0.000 | 1.425±0.164 | 1.403±0.227 | 1.186±0.090 | 1.099±0.048 | 1.071±0.054 | 1.056±0.055 | ||||
| RBV (40 mg/100 µl) | Ex. | 1.000±0.000 | 1.075±0.035 | 1.055±0.039 | 1.090±0.080 | 1.135±0.088 | 1.157±0.108 | 1.221±0.066 | 8.525 (0.000)* | 59.847 (0.000)* | 9.386 (0.000)* |
| Co. | 1.000±0.000 | 1.514±0.116 | 1.322±0.151 | 1.124±0.113 | 1.147±0.087 | 1.104±0.035 | 1.157±0.065 | ||||
| Melittin (0.5 mg/100 µl) | Ex. | 1.000±0.000 | 1.127±0.120 | 1.294±0.238 | 1.182±0.063 | 1.124±0.085 | 1.084±0.060 | 1.279±0.385 | 2.234 (0.062) | 0.298 (0.605) | 0.621 (0.712) |
| Co. | 1.000±0.000 | 1.201±0.142 | 1.184±0.091 | 1.213±0.132 | 1.231±0.076 | 1.150±0.081 | 1.176±0.042 | ||||
| Melittin (1.0 mg/100 µl) | Ex. | 1.000±0.000 | 1.263±0.077 | 1.283±0.112 | 1.118±0.067 | 1.198±0.059 | 1.131±0.078 | 1.110±0.127 | 5.828 (0.493) | 0.106 (0.756) | 0.897 (0.130) |
| Co. | 1.000±0.000 | 1.311±0.147 | 1.140±0.133 | 1.184±0.038 | 1.202±0.063 | 1.162±0.063 | 1.145±0.204 | ||||
| Melittin (1.5 mg/100 µl) | Ex. | 1.000±0.000 | 1.052±0.043 | 1.303±0.355 | 1.158±0.071 | 1.077±0.049 | 1.067±0.018 | 1.057±0.033 | 3.013 (0.093) | 0.018 (0.898) | 1.377 (0.290) |
| Co. | 1.000±0.000 | 1.114±0.056 | 1.089±0.073 | 1.228±0.202 | 1.085±0.040 | 1.109±0.084 | 1.056±0.027 | ||||
| Apamin (0.5 mg/100 µl) | Ex. | 1.000±0.000 | 1.288±0.159 | 1.098±0.081 | 1.108±0.042 | 1.087±0.022 | 1.102±0.055 | 1.101±0.065 | 5.991 (0.000)* | 1.195 (0.316) | 2.621 (0.133) |
| Co. | 1.000±0.000 | 1.136±0.094 | 1.171±0.076 | 1.234±0.126 | 1.142±0.032 | 1.126±0.036 | 1.108±0.063 | ||||
| Apamin (1.0 mg/100 µl) | Ex. | 1.000±0.000 | 1.447±0.197 | 1.337±0.259 | 1.149±0.028 | 1.121±0.030 | 1.088±0.048 | 1.078±0.138 | 2.649 (0.134) | 0.009 (0.929) | 2.021 (0.192) |
| Co. | 1.000±0.000 | 1.153±0.074 | 1.240±0.156 | 1.130±0.035 | 1.080±0.056 | 1.107±0.083 | 1.466±0.683 | ||||
| Apamin (1.5 mg/100 µl) | Ex. | 1.000±0.000 | 1.175±0.101 | 1.211±0.073 | 1.181±0.055 | 1.133±0.055 | 1.145±0.062 | 1.114±0.044 | 6.941 (0.015)* | 0.727 (0.426) | 0.187 (0.798) |
| Co. | 1.000±0.000 | 1.180±0.179 | 1.186±0.091 | 1.127±0.035 | 1.089±0.057 | 1.117±0.080 | 1.094±0.037 | ||||
| BBM (100 µl/100 µl) | Ex. | 1.000±0.000 | 1.079±0.082 | 1.075±0.021 | 1.166±0.105 | 1.229±0.256 | 1.160±0.155 | 1.146±0.134 | 4.531 (0.026)* | 12.531 (0.012)* | 3.429 (0.052) |
| Co. | 1.000±0.000 | 1.419±0.118 | 1.137±0.084 | 1.284±0.088 | 1.151±0.040 | 1.126±0.051 | 1.049±0.038 | ||||
| BBM (200 µl/100 µl) | Ex. | 1.000±0.000 | 1.072±0.028 | 1.225±0.150 | 1.090±0.055 | 1.219±0.099 | 1.297±0.072 | 1.167±0.061 | 6.476 (0.000)* | 1.311 (0.296) | 7.387 (0.000)* |
| Co. | 1.000±0.000 | 1.387±0.103 | 1.168±0.101 | 1.218±0.083 | 1.181±0.067 | 1.095±0.100 | 1.160±0.081 | ||||
| BBM (300 µl/100 µl) | Ex. | 1.000±0.000 | 1.130±0.098 | 1.016±0.008 | 1.109±0.076 | 1.165±0.098 | 1.144±0.170 | 1.163±0.068 | 3.978 (0.004)* | 5.201 (0.063) | 2.683 (0.030)* |
| Co. | 1.000±0.000 | 1.284±0.107 | 1.186±0.094 | 1.113±0.578 | 1.090±0.061 | 1.140±0.077 | 1.078±0.054 | ||||
Values are presented as mean±standard deviation. RBV: raw bee venom, BBM: bee venom based mist, Ex.: experimental group, Co.: control group, Time×group: group interaction over time interval. *Statistically significant with p<0.05.