Table 2. Percentage of individuals within each group achieving the clinically significant response for FSH or LH during GnRH stimulation at increasing dose concentrations.
| GnRH 100 μg | Time Point (minutes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | 15 | 30 | 60 | 120 | 180 | ||||
| Critical Response Achieved | FSH | 50% ↑ from BL | Control- Eugonadal | 11 | 45% | 82% | 64% | 55% | 55% |
| Control- Hypogonadal | 27 | 59% | 63% | 74% | 67% | 59% | |||
| SCI- Eugonadal | 16 | 69% | 69% | 75% | 75% | 56% | |||
| SCI- Hypogonadal | 14 | 71% | 86% | 79% | 79% | 71% | |||
| LH | 2-fold ↑ from BL | Control- Eugonadal | 11 | 82% | 100% | 91% | 73% | 18% | |
| Control- Hypogonadal | 27 | 81% | 85% | 81% | 70% | 48% | |||
| SCI- Eugonadal | 16 | 75% | 75% | 75% | 56% | 56% | |||
| SCI- Hypogonadal | 14 | 86% | 79% | 79% | 64% | 50% | |||
| Diagnostic Agreement | Control- Eugonadal | 27% | 82% | 55% | 55% | 18% | |||
| Control- Hypogonadal | 59% | 63% | 67% | 63% | 44% | ||||
| SCI- Eugonadal | 63% | 56% | 69% | 50% | 44% | ||||
| SCI- Hypogonadal | 64% | 71% | 64% | 50% | 43% | ||||
| GnRH 50 μg | Time Point (minutes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | 15 | 30 | 60 | 120 | 180 | ||||
| Critical Response Achieved | FSH | 50% ↑ from BL | Control- Eugonadal | 11 | 64% | 100% | 82% | 82% | 55% |
| Control- Hypogonadal | 27 | 59% | 78% | 78% | 63% | 67% | |||
| SCI- Eugonadal | 16 | 81% | 94% | 100% | 100% | 81% | |||
| SCI- Hypogonadal | 14 | 71% | 86% | 79% | 86% | 79% | |||
| LH | 2-fold ↑ from BL | Control- Eugonadal | 11 | 91% | 91% | 91% | 64% | 64% | |
| Control- Hypogonadal | 27 | 89% | 89% | 85% | 63% | 59% | |||
| SCI- Eugonadal | 16 | 94% | 100% | 94% | 75% | 63% | |||
| SCI- Hypogonadal | 14 | 86% | 93% | 93% | 79% | 64% | |||
| Diagnostic Agreement | Control- Eugonadal | 55% | 73% | 82% | 64% | 45% | |||
| Control- Hypogonadal | 52% | 70% | 67% | 44% | 37% | ||||
| SCI- Eugonadal | 75% | 94% | 94% | 75% | 63% | ||||
| SCI- Hypogonadal | 64% | 79% | 71% | 71% | 50% | ||||
| GnRH 10 μg | Time Point (minutes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | 15 | 30 | 60 | 120 | 180 | ||||
| Critical Response Achieved | FSH | 50% ↑ from BL | Control- Eugonadal | 11 | 64% | 91% | 73% | 36% | 27% |
| Control- Hypogonadal | 27 | 56% | 44% | 56% | 52% | 52% | |||
| SCI- Eugonadal | 16 | 63% | 63% | 56% | 63% | 50% | |||
| SCI- Hypogonadal | 14 | 64% | 79% | 71% | 57% | 64% | |||
| LH | 2-fold ↑ from BL | Control- Eugonadal | 11 | 82% | 82% | 73% | 55% | 45% | |
| Control- Hypogonadal | 27 | 78% | 89% | 52% | 37% | 26% | |||
| SCI- Eugonadal | 16 | 75% | 63% | 56% | 56% | 44% | |||
| SCI- Hypogonadal | 14 | 79% | 71% | 71% | 50% | 43% | |||
| Diagnostic Agreement | Control- Eugonadal | 55% | 73% | 64% | 27% | 18% | |||
| Control- Hypogonadal | 44% | 41% | 30% | 30% | 22% | ||||
| SCI- Eugonadal | 56% | 56% | 50% | 56% | 31% | ||||
| SCI- Hypogonadal | 50% | 57% | 50% | 36% | 36% | ||||
Data are presented as percentage of responders by group. GnRH=gonadotropin releasing hormone; FSH=follicle stimulating hormone; LH=luteinizing hormone; BL=baseline; μg=micrograms.