Table 2.
Reasons for discontinuation of BoNT treatment in CD
| Reason | Kessler et al., 1999 | Brashear et al., 2000 | Hsiung et al., 2002 | Haussermann et al., 2004 | Skogseid and Kerty, 2005 | Gill et al., 2013 | TOTAL |
|---|---|---|---|---|---|---|---|
| Total Cases | 155 | 51 | 49 | 33 | 14 | 21 | 272 |
| Primary non-response | 19.3% (33) | 21.6 % (11) | 22.4% (11) | 3.0% (1) | 14.3% (2) | 14.3% (3) | 18.4% (50) |
| Secondary non-response | 9.9% (17) | 3.9 % (2) | 18.4% (9) | 9.1% (3) | NR | 38.1% (8) | 13.6% (37) |
| Adverse events | 15.8% (27) | 27.4 % (14) | 6.1% (3) | 33.3% (11) | NR | 9.5% (2) | 15.8% (43) |
| Improved/remitted | 15.2% (26) | NR | 8.2% (4) | 18.2% (6) | 35.7% (5) | 4.8% (1) | 15.4% (42) |
| Moved | 21.1% (36) | 2.0 % (1) | 6.1% (3) | NR | NR | NR | 14.3% (39) |
| Inconvenience | NR | 13.7 % (7) | 6.1% (3) | 36.4% (12) | NR | 9.5% (2) | 6.2% (17) |
| Cost | NR | 13.7 % (7) | 4.1% (2) | NR | NR | 23.8%. (5) | 2.5% (7) |
| Other | 17.4% (27) | 31.4 % (16) | 2.0% (1) | NR | 35.7% (5) | 4.8% (1) | 11.8% (32) |
| Lost to follow up | 4.1% (7) | 43.1% (22) | 26.5% (13) | NR | 14.3% (2) | NR | 8.1% (22) |
Values show percent of total patients and actual number in parentheses discontinuing treatment at their study center. Percentages may add up to more than 100 if patients gave more than one reason. The “other” category includes pregnancy, death, other illness, preference for other treatments, unknown, or discontinuation by physician for unspecified reasons. NR=not reported.