. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Spinal Cord. 2017 Nov 8;56(3):212–217. doi: 10.1038/s41393-017-0018-2

Table 2.

Reported Side Effects

Side Effects	IV	Low TD	High TD
Eye/Facial Twitching^*	23/25 (92%)	2/21 (10%)	4/16 (25%)
Abdominal Distention	10/25 (40%)	4/21 (19%)	7/16 (44%)
Abdominal Cramping	13/25 (52%)	4/21 (19%)	5/16 (31%)
Dry Mouth^†	14/25 (56%)	5/21 (24%)	2/16 (13%)
Diaphoresis	8/25 (32%)	3/21 (14%)	3/16 (19%)
Drowsiness	6/25 (24%)	4/21 (19%)	1/16 (6%)
Lightheadedness^¥	7/25 (28%)	2/21 (10%)	0
Headache^**	4/25 (16%)	0	0

Data reported as number and percentage of subjects reporting the defined side effects. IV=Intravenous. TD=Transdermal Dose.

p<0.001;

^†

p=0.006;

^¥

p=0.029;

^**

p=0.039

[All comparisons are an analysis of variance between all three group]