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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Orthop Res. 2017 Oct 17;36(2):760–769. doi: 10.1002/jor.23728

Figure 1.

Figure 1

Stress-strain characteristics and cell viability for compressive loading parameters. A. Equilibrium strains of cartilage explants were measured using an Electro-Force 3100 Mechanical Testing System operated in load-control. Loads ranging from 8 – 500kPa stresses were applied to explants in unconfined compression (N=2–4 per stress level). Stress levels of 50kPa and 300kPa were selected to generate strains of approximately 15% and 40% in subsequent experiments. B. Chondrocyte viability decreased with loading from 94% to ~80%, but it did not differ between a physiologic loading condition (cyclic 50kPa loading) and a hyper-physiologic loading condition (static 300kPa loading). Viability was assessed by confocal microscopy in 3 separate regions per explant per animal (N=4). Bars not sharing a letter are significantly different from each other (p<0.05). Values are mean ± SEM.