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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Orthop Res. 2017 Oct 17;36(2):760–769. doi: 10.1002/jor.23728

Figure 4.

Figure 4

Effect of 50 and 300 kPa intermittent cyclic compressive loading on the expression of cartilage antioxidant and glutathione synthesis and cellular detoxification genes. Data are expressed as a fold-change relative to average unloaded control samples. Both loading magnitudes down-regulated the expression of numerous genes, including superoxide dismutase 3 (SOD3), catalase (CAT), peroxiredoxin 3 (PRDX3), glutathione synthetase (GSS), and gamma-glutamyltransferase-1 (GTT1). Some genes, however, were differentialy regulated, including superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), glutamate-cysteine ligase catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM). Peroxiredoxin 5 (PRDX5) was the only gene whose expression was unaltered by loading. Y-axis is log-2 scale; N=3 per loading group. *p<0.05 from unloaded controls; #p<0.05 between loading magnitudes. Values are mean ± SEM.