Table 1.
Inhibition of Oral Tumorigenesis by BRB in DB[a,l]PDE treated mice
| Treatments | ||
|---|---|---|
| DB[a,l]PDE | DB[a,l]PDE+BRB | |
| Number of mice1 | 29 | 29 |
| Total (M + B) | 27 (93)2 | 19 (66)* |
| Benign Tumors (B) | 26 (90)3 | 9 (31)*** |
| Malignant Tumors (M) | 15 (52)4 | 13 (45) |
1
Mice which died before the first tumor appeared in the study or did not reach histology due to cannibalism were not counted.
2
Number in parentheses, percentage of mice developed tumors.
3
Benign tumors induced by DB[a,l]PD consist of papilloma and keratoacanthoma; papilloma accounted for 94.7%.
4
Malignant tumors induced by DB[a,l]PDE consist of squamous cell carcinoma, invasive anaplastic cell carcinoma and fibrosarcoma; squamous cell carcinoma accounted for 88.8%.
*
tumor incidence was significantly reduced compared to DBPDE treatment, p < 0.05.
***
tumor incidence was significantly reduced compared to DBPDE treatment, p < 0.001.