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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2017 Dec 5;29(3):516–526. doi: 10.1007/s13361-017-1851-4

Figure 4.

Figure 4

Localization of irinotecan and its metabolites in a 24 h treated CTO. (a) MALDI-MSI ion images and summed spectra of distribution of irinotecan (m/z 587.3), SN-38 (m/z 393.1), and SN-38G (m/z 569.2). (b) Correlation analysis to evaluate co-localization of irinotecan and its metabolites in the CTO. The left plot shows the correlation of irinotecan (m/z 587.3) and SN-38 (m/z 393.1). The middle plot shows the correlation of irinotecan (m/z 587.3) and SN-38G (m/z 569.2). The right plot shows the correlation of SN-38G (m/z 569.2) and SN-38 (m/z 393.1).