Table 1.
Genotype and allele frequencies for GRIN2A rs4998386 in Parkinson’s disease
| Allele frequency (%) | Genotype counts (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| N | C | T | HWE P-value |
CC | CT | TT | RR (95% CI) | p-value | |
| HPFS | |||||||||
| PD | 286 | 527 (92.1) | 45 (7.9) | 242 (84.6) | 43 (15.0) | 1 (0.4) | 0.98 (0.68, 1.42)* | 0.92 | |
| Control | 964 | 1,764 (91.5) | 164 (8.5) | 0.40 | 809 (83.9) | 146 (15.2) | 9 (0.9) | 0.95 (0.65, 1.40)** | 0.81 |
|
| |||||||||
| NHS | |||||||||
| PD | 393 | 692 (88.0) | 94 (12.0) | 301 (76.6) | 90 (22.9) | 2 (0.5) | 0.82 (0.63, 1.07)* | 0.15 | |
| Control | 1,625 | 2,902 (89.3) | 348 (10.7) | 0.23 | 1,291 (79.5) | 320 (19.7) | 14 (0.9) | 0.80 (0.61, 1.05)** | 0.11 |
|
| |||||||||
| CPS-IIN† | |||||||||
| PD | 150 | 264 (88.0) | 36 (12.0) | 114 (76.0) | 36 (24.0) | 0 (0.0) | 0.88 (0.50, 1.56)* | 0.66 | |
| Control | 165 | 295 (89.4) | 35 (10.6) | 0.13 | 130 (78.8) | 35 (21.2) | 0 (0.0) | ||
|
| |||||||||
| HPFS, NHS, CPS-IIN | |||||||||
| PD | 829 | 1,483 (89.5) | 175 (10.6) | 657 (79.3) | 169 (20.4) | 3 (0.4) | 0.88 (0.72, 1.07)* | 0.20 | |
| Control | 2,754 | 4,961 (90.1) | 547 (9.9) | 0.38 | 2,230 (81.0) | 501 (18.2) | 23 (0.8) | 0.85 (0.70, 1.05)** | 0.13 |
*
Dominant model (CC vs. CT/TT)
**
Model excluding the rs4998386_TT genotype
†
There were no participants with the TT genotype for CPS-IIN