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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Hum Mutat. 2018 Jan 16;39(4):471–494. doi: 10.1002/humu.23395

Figure 4. Multiple sequence alignment of HSF4 protein sequences.

Figure 4

Protein sequences for HSF4 downloaded from UCSC browser for Homo sapiens, Mus musculus, Gallus gallus, Xenopus tropicalis and Danio rerio shows amino acid conservation across different vertebrate species. Amino acid changes caused by specific human mutations are indicated by yellow arrowheads. The sequence consensus is presented for each amino-acid. HSF-DNA binding domain and vertebrate heat shock transcription factor domains are indicated by green arrow.