Skip to main content
. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: J Immunol. 2018 Feb 9;200(6):1988–1994. doi: 10.4049/jimmunol.1701328

FIGURE 1. Lack of corticosterone production in Cyp11b1 exon 3-5-/- (Cyp11b1-/- mice) mice.

FIGURE 1

(A) Corticosterone concentrations in the supernatants of adrenals from WT and Cyp11b1-/- mice cultured for three days in the absence or presence of metyrapone. Adrenals from each mouse were cultured in the absence or presence of 200 μg/ml metyrapone. (B) Corticosterone levels in plasma from WT, Cyp11b1foxN1-Cre, and Cyp11b1-/- mice. (C) Corticosterone levels in plasma from WT and Cyp11b1-/- mice 3 hr after injection LPS or PBS alone. (D) Cyp11b1-/- mice exhibit adrenal hyperplasia. Weights of adrenals from WT and Cyp11b1-/- mice. All data in this figure are shown as the mean ± SEM with n=3. *P < 0.05, **P < 0.005.