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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: J Immunol. 2018 Feb 9;200(6):1977–1981. doi: 10.4049/jimmunol.1700416

Figure 4. T-bet, but not Eomes, is required for the maintenance of memory NK cells.

Figure 4

WT (CD45.1) and Eomesf/f x UbCre-ERT2 (CD45.2, A–C) or Tbx21f/f x UbCre-ERT2 (CD45.2, D–F) NK cells were co-transferred into Ly49h−/− mice, which were infected with MCMV and treated with tamoxifen (or oil alone) at 3 weeks PI. (A and D) The relative fold change of floxed and WT populations two weeks following tamoxifen treatment relative to their starting ratio is shown. (B and E) Assessment of phenotypic markers for the spleen and liver are shown. (C and F) MFI of KLRG1 staining in the spleen is shown. Data are mean ± SEM representative of three independent experiments with at least n=3 biological replicates per condition. * p < 0.05 and ns, not significant, paired Student t-test.