Table 1.
Histological validation of ECV by modality
| Reference | Year | Population | Number | Finding |
|---|---|---|---|---|
| ECV by CMR | ||||
| Flett et al. [15] | 2010 | AS/HCM | 26 | Strong correlation with histological fibrosis in AS (r2 = 0.86) and HCM (r2 = 0.62). |
| White et al. [21] | 2013 | AS | 18 | Bolus only and infusion ECV measurements correlated with histological CVF (r2 = 0.69 and 0.71). |
| Miller et al. [17] | 2013 | DCM/IHD (transplant) | 6 | Significant linear relationship with histological CVF using either the 10- or 15-min post-contrast T1 (p < 0.001). |
| De Meester et al. [16] | 2015 | AS/AR/MR | 31 | Strong correlation with the magnitude of histological fibrosis (r = 0.78). |
| Kammerlander et al. [18] | 2016 | Mixed HF | 36 | Significant correlation with histological CVF (r = 0.493). |
| Lurz et al. [19] | 2016 | Myocarditis | 129 | ECV adequately estimated the degree of LV fibrosis percentage only in patients without inflammation (r = 0.72) and not in those with inflammation (r = 0.24). |
| ECV by CT | ||||
| Bandula et al. [34] | 2013 | AS | 23 | Strong correlation with histological measures of fibrosis (r = 0.71). |
| Yoon et al. [43] | 2015 | Hepatic fibrosis | 141 | Significant correlation with histological hepatic fibrosis staging (r = 0.493). |
AS aortic stenosis, AR aortic regurgitation, CVF collagen volume fraction, DCM dilated cardiomyopathy, HCM hypertrophic cardiomyopathy, HF heart failure, IHD ischemic heart disease, MR mitral regurgitation