Table 3.
Antibacterial activity of the RRWQWR-based peptides against the ATCC strains of HCAI-relevant bacteria.
| Bacterium | Enterococcus faecalis | Pseudomonas aeruginosa | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Strain ATCC# | Sensitive 29212 | Resistant 51575 | Sensitive 10145 | Resistant 27853 | |||||
| Peptide | Alternate name | MIC50 (μM) | MBC (μM) | MIC50 (μM) | MBC (μM) | MIC50 (μM) | MBC (μM) | MIC50 (μM) | MBC (μM) |
| LfcinB (20–25) | Monomer | >200.0 | >200.0 | 198.0 | >200.0 | >200.0 | >200.0 | >200.0 | >200.0 |
| PLS | Palindromic | 25.6 | 100.0 | >200.0 | >200.0 | 99.7 | >200.0 | 107.2 | >200.0 |
| LfcinB (17–31) | Reference | 34.3 | >200.0 | >200.0 | >200.0 | 111.7 | >200.0 | 99.6 | >200.0 |
| LfcinB (20–25)2 | Dimeric | 13.1 | 100.0 | >200.0 | >200.0 | 29.1 | 100.0 | 34.8 | 200.0 |
| LfcinB (20–25)4 | Tetrameric | 3.1 | 25.0 | >200.0 | >200.0 | 18.1 | 50.0 | 21.7 | 50.0 |