Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 6;8:4092. doi: 10.1038/s41598-018-22384-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Loss of distinct up-regulated E3 enzymes induces changes in the hESC proteome. (a) Loss of UBR7 changed the levels of 506 proteins in H9 hESCs (FDR <0.2 was considered significant, n = 3). GOBP analysis (P < 0.05) revealed a strong enrichment for regulators of the purine metabolic process as well as generation of energy and metabolites. (b) Loss of UBE3A changed the levels of 661 proteins in H9 hESCs (FDR < 0.2 was considered significant, n = 3). Bar graph representing the top GOBPs changed upon UBE3A KD (P < 0.05). (c) Loss of RNF181 changed the levels of 202 proteins in H9 hESCs (FDR < 0.2, n = 3). Bar graph representing the top GOBPs changed upon RNF181 KD (P < 0.05). (d) Common proteins between interacting partners of E3 ubiquitin ligases and proteins up-regulated in hESCs with knockdown of the respective E3 enzymes.