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. 2018 Feb 5;7(1):11–31.

Figure 1.

Figure 1

Comparison of human TDP-43 and Drosophila TBPH. A. Sequence alignment of human TDP-43 (414 amino acids) and Drosophila TBPH (531 amino acids). Identical amino acids are dark-shaded, and similar or related amino acids are light-shaded. The amino acid sequence of TBPH was retrieved from FlyBase and compared with that of human TDP-43 using FASTA and BLAST. B. Schematic drawings of the domain structures of human TDP-43 and Drosophila TBPH proteins. TDP-43 and TBPH comprise two RNA recognition motifs (RRM1 and RRM2) and a C-terminal Gly-rich region. The human TDP-43 domain is highly conserved in Drosophila TBPH. The solid line under the schematic of Drosophila TBPH shows the target genomic sequence of each of the two RNAi transgenes employed in this study, UAS-TBPH-IR81-181 and UAS-TBPH-IR517-531.