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. 2018 Mar 6;8:4080. doi: 10.1038/s41598-018-21728-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Components of the activation mechanism of prothrombin. (top) Value of the rate of ligand dissociation k_off for prothrombin (ProT) and its derivatives prethrombin-1 (Pre1), prethrombin-2 (Pre2), meizothrombin (MzT) and thrombin (T). The value drops drastically when cleavage at R320 triggers the Huber-Bode mechanism of activation and produces either meizothrombin or thrombin. (bottom) Distribution of E* (red bar) and E (blue bar) for prothrombin and its derivatives. The E* population gradually decreases as the auxiliary domains of prothrombin are removed in the zymogen and activation to the mature enzyme ensues. The values reported in the figure are derived from Table 1.