Fig. 5.
Replication in UK Biobank. a Forest plot of overall effect size for rs6702619 in the discovery (QUEBEC-CAVS) and validation (UK Biobank) cohorts. The blue filled squares represent the odds ratio (OR) for each cohort with 95% confidence intervals illustrated by horizontal lines. The gray vertical line represents an OR of 1.0 and the dashed magenta line is the OR of the meta-analysis. b Manhattan plot showing the GWAS in UK Biobank comparing 1391 CAVS cases and 352,195 controls. The horizontal blue and magenta lines indicate PGWAS values of 1 × 10−5 and 5 × 10−8, respectively. Three SNPs were significant at the PGWAS threshold of 5 × 10−8: rs74617384 and rs10455872 at the LPA locus and rs7543130 (in perfect LD with rs6702619) at the PALMD locus