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. 2018 Mar 6;8:4069. doi: 10.1038/s41598-018-22447-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron micrographs of the steps of gJ-deleted mutant virus lifecycle. (A) Capsids in the nucleus. (B) Primary envelopment, showing the close apposition of the particles and the inner nuclear membrane (INM). (C) Primarily enveloped particles present within the perinuclear space. (D) Particles in the cytoplasm, showing the close apposition of the particles and the Golgi or trans-Golgi network (TGN). (E) Initial steps of secondary envelopment. The unenveloped capsids in the cytoplasm interacted with TGN membrane and was being wrapped in these membranes. (F) Final steps of secondary envelopment. Enveloped particles were present with the TGN-derived membranes. (G) and (H) Virions release. Enveloped virions are transported to cell surface and released. (I) Virion in the extracellular medium.