Table 4.
Multivariable risk estimates (ORs) for LBD (DLB + PDD) patients compared to AD patients
| n (%) | Crude ORa (95% CI) | Multivariable ORb (95%CI) | ||
|---|---|---|---|---|
| AD (n = 78) | LBD (n = 89) | |||
| Antiparkinson drugs | 10 (12.8) | 53 (59.6) | 10.01 (4.56–22.00) p < .001 | c |
| SBP, mmHg | ||||
| 1st tertile (87–128) | 16 (20.5) | 39 (43.8) | 1 | 1 |
| 2nd tertile (129–143) | 25 (31.1) | 29 (32.6) | 0.41 (0.13–1.27) | 0.54 (0.20–1.45) |
| 3rd tertile (144–198) | 37 (47.4) | 21 (23.6) | 0.20 (0.06–0.71) p = 013 | 0.28 (0.10‐0.76) p = .012 |
| DBP, mmHg | ||||
| 1st tertile (48–66) | 23 (23.8) | 30 (33.7) | 1 | c |
| 2nd tertile (67–76) | 23 (38.9) | 32 (36.0) | 2.21 (0.67–7.30) | c |
| 3rd tertile (77–98) | 32 (37.3) | 27 (30.3) | 1.83 (0.54–6.22) | c |
| Fasting glucose, mg/dl | ||||
| 1st tertile (69–102) | 20 (25.6) | 34 (38.2) | 1 | c |
| 2nd tertile (103–118) | 22 (28.2) | 34 (38.2) | 1.57 (0.52–4.70) | c |
| 3rd tertile (119–349) | 36 (46.2) | 21 (23.6) | 0.64 (0.19–2.11) | c |
| HbA1c, mmol/mol | ||||
| 1st tertile (4.2–6.7) | 17 (21.8) | 40 (44.9) | 1 | 1 |
| 2nd tertile (6.8–7.2) | 17 (21.8) | 39 (43.8) | 0.68 (0.24–1.95) | 0.72 (0.28–1.84) |
| 3rd tertile (7.3–11.6) | 44 (56.4) | 10 (11.2) | 0.19 (0.06–0.65) p = .008 | 0.15 (0.05–0.41) p < .001 |
| BMI, kg/m2 | ||||
| 1st tertile (15.6–23.5) | 13 (16.7) | 43 (48.3) | 1 | 1 |
| 2nd tertile (23.6–26.4) | 32 (41.0) | 24 (27.0) | 0.20 (0.06–0.62) p = .006 | 0.29 (0.11–0.76) p = .012 |
| 3rd tertile (26.5–32.2) | 33 (42.3) | 22 (24.7) | 0.34 (0.11–1.06) | 0.42 (0.15–1.16) |
| TG, mg/dl | ||||
| 1st tertile (23–90) | 13 (16.7) | 41 (46.7) | 1 | 1 |
| 2nd tertile (91–126) | 21 (26.9) | 38 (42.1) | 0.63 (0.22–1.82) | 0.62 (0.25–1.58) |
| 3rd tertile (127–310) | 44 (56.4) | 10 (11.2) | 0.08 (0.02–0.30) p < .001 | 0.13 (0.04–0.36) p < .001 |
| Total cholesterol, mg/dl | ||||
| 1st tertile (104–154) | 27 (34.6) | 26 (29.2) | 1 | c |
| 2nd tertile (155–189) | 28 (35.9) | 34 (38.2) | 2.47 (0.71–8.63) | c |
| 3rd tertile (191–282) | 23 (29.5) | 29 (32.6) | 13.64 (2.10–88.71) p = .006 | c |
| LDL, mg/dl | ||||
| 1st tertile (37–95) | 26 (33.3) | 29 (32.6) | 1 | c |
| 2nd tertile (96–121) | 24 (30.8) | 35 (35.8) | 0.76 (0.21–2.75) | c |
| 3rd tertile (122–203) | 28 (35.9) | 25 (28.1) | 0.20 (0.01–1.18) | c |
n, number of cases; AD, Alzheimer's disease; LBD, Lewy body dementia; DLB, dementia with Lewy bodies; PDD, Parkinson's disease dementia; HbA1c, glycated hemoglobin; BMI, body mass index; TG, triglyceride; LDL, low‐density lipoprotein.
a
Crude ORs are adjusted for age and sex.
b
Multivariable ORs are derived from a stepwise procedure that considered age, sex, disease severity, antiparkinson drugs, systolic and diastolic blood pressures, glycated hemoglobin, body mass index, triglyceride, total cholesterol, and low‐density lipoprotein.
c
ORs absent for variables not included in multivariable regression analysis.