Figure 1.

Groups of mice with and without 2 weeks of social isolation, followed by treatment with 5‐HT _2CR antagonist SB243213/5‐HT _2CR inverse agonist SB206553. Sixty healthy male BALB/c mice at the age of 21 days old were randomly divided into six groups, with 10 mice in each group. Each mouse was placed in a plastic cage (five mice per cage). The mice treated with physiological saline (20 ml/kg, i.p.) were individually housed for 2 weeks. The animals were labeled SI group (social isolation group, n = 10). In addition, the recovery of the behavioral deficit by 5‐HT _2C R antagonist SB243213/5‐HT _2C R inverse agonist SB206553 treatment (0.5 mg/kg, i.p.) was also examined. The treated groups were labeled SI + SB243213 group and SI + SB206553 group (recovery groups with drug treatments, n = 10/group). The age‐matched gregarious mice treated with physiological saline (20 ml/kg, i.p.) was labeled C group (normal control group, n = 10); meanwhile, the age‐matched gregarious mice treated with the 5‐HT _2C R antagonist SB243213/5‐HT _2C R inverse agonist SB206553 (0.5 mg/kg, i.p.) were labeled C+SB243213 and C+SB206553 (drug treatment alone groups, n = 10/group) groups, respectively