Table 2.
p‐Values of the analysis by two‐way ANOVA
| Social isolation | Drug treatment | Social isolation × Drug treatment | |
|---|---|---|---|
| Latency of first bit | .000 | .013 | .000 |
| Duration of biting genitals | .000 | .000 | .000 |
| BLA | .000 | .045 | .000 |
| LaDL | .000 | .002 | .000 |
| LaVL | .005 | .001 | .001 |
| LaVM | .016 | .001 | .000 |
| Western Blot | .014 | .060 | .080 |
| Htr2c RNA editing | .039 | .860 | .006 |
LaDL, lateral amygdaloid nucleus, dorsolateral part; LaVM, lateral amygdaloid nucleus, ventromedial part; LaVL, lateral amygdaloid nucleus, ventrolateral part LaVL; BLA, basolateral amygdaloid.
The analysis results of two‐way ANOVA showed that there was an interaction between social isolation and drug treatment (two independent variables) on aggressive behavior, ADAR1 expression, and Htr2c RNA editing (dependent variable) among mice. Both isolation and drug treatment were associated with aggressive behavior, ADAR1 expression, and Htr2c RNA editing.