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. 2018 Mar;188(3):768–784. doi: 10.1016/j.ajpath.2017.10.022

Figure 1.

Figure 1

Metanephric mesenchymal (MM) cells express both mesenchymal and endothelial characteristics. MM cell lysates were examined by immunoblotting for expression of mesenchymal and endothelial markers. A and B: MM cells express mesenchymal marker proteins vimentin, α-smooth muscle actin (α-SMA), platelet-derived growth factor receptor (PDGFR)-β, forkhead box D1 (Foxd1), and glioma-associated oncogene homolog 1 (Gli-1) (A), as well as endothelial markers aquaporin 1 (AQP1), Flk-1 (vascular endothelial growth factor receptor 1), Flt-1 (VEGFR2), and Tie-2 (angiopoietin receptor) (B). C: MM cells also endocytose acetylated low-density lipoprotein (Ac-LDL), a functional characteristic of endothelial cells. Original magnification, ×20 (C).