Representative images of low and high hedgehog pathway protein expression in malignant prostate tissue cores. Tissue cores were stained for Sonic hedgehog (SHH), Patched 1 (PTCH1), Smoothened (SMO), suppressor of fused (SUFU), glioma-associated oncogene (GLI) 1, GLI2, GLI3, cyclin D1, snail family transcriptional repressor 1 (SNAIL), and snail family transcriptional repressor 3 (SNAI3). Original magnification, ×100.