. 2018 Mar;188(3):795–804. doi: 10.1016/j.ajpath.2017.11.019

Table 3.

Correlations between Hh Proteins in the Epithelial and Stromal Cells in the Tumor and Benign Prostate Tissue

Variable	Epithelial expression										Stromal expression
Variable	SNAIL	GLI1	SMO	SNAI3	SHH	GLI3	GLI2	SUFU	Cyclin D1	PTCH1	GLI1	SMO	SNAI3	SHH	GLI3	GLI2	SUFU	PTCH1
Tumor
Epithelial
SNAIL	1.00^‡	0.45^†	0.41^†	0.33^∗	0.28^∗	0.25^∗	0.35^∗	0.39^∗		0.26^∗		0.59^†	0.38^∗	0.36^∗	0.40^†	0.25^∗
GLI1	0.45^†	1.00^‡	0.41^†	0.40^†	0.54^†	0.47^†	0.30^∗	0.40^†			0.27^∗	0.45^†	0.35^∗
SMO	0.41^†	0.41^†	1.00^‡	0.58^†	0.52^†	0.38^†	0.27^∗		0.31^∗			0.38^∗	0.28^∗
SNAI3	0.33^∗	0.40^†	0.58^†	1.00^‡	0.44^†	0.40^†	0.39^∗					0.29^∗	0.42^†
SHH	0.28^∗	0.54^†	0.52^†	0.44^†	1.00^‡			0.34^∗				0.29^∗	0.27^∗
GLI3	0.25^∗	0.47^†	0.38^∗	0.40^†		1.00^‡	0.50^†					0.39^∗	0.43^†		0.26^∗
GLI2	0.35^∗	0.30^∗	0.27^∗	0.39^∗		0.50^†	1.00^‡	0.25^∗				0.39^∗	0.40^†			0.30^∗		0.27^∗
SUFU	0.39^∗	0.40^†			0.34^∗		0.25^∗	1.00^‡			0.32^∗	0.49^†	0.35^∗		0.40^†		0.53^†
Cyclin D1			0.31^∗						1.00^‡
PTCH1	0.26^∗									1.00^‡								0.26^∗
Stromal
GLI1		0.27^∗						0.32^∗			1.00^‡	0.41^†		0.29^∗	0.44^†	0.34^∗	0.44^†
SMO	0.59^†	0.45^†	0.38^∗	0.29^∗	0.29^∗	0.39^†	0.39^∗	0.49^†			0.41^†	1.00^‡	0.53^†	0.61^‡	0.65^‡	0.42^†	0.32^∗	0.26^∗
SNAI3	0.38^∗	0.35^∗	0.28^∗	0.42^†	0.27^∗	0.43^†	0.40^†	0.35^∗				0.53^†	1.00^‡		0.35^∗
SHH	0.36^∗										0.29^∗	0.61^‡		1.00^‡	0.49^†	0.52^†	0.26^∗
GLI3	0.40^†					0.26^∗		0.40^†			0.44^†	0.65^‡	0.35^∗	0.49^†	1.00^‡	0.43^†	0.30^∗
GLI2	0.25^∗						0.30^∗				0.34^∗	0.42^†		0.52^†	0.43^†	1.00^‡
SUFU								0.53^†			0.44^†	0.32^∗		0.26^∗	0.30^∗		1.00^‡
PTCH1							0.27^∗			0.26^∗		0.26^∗						1.00^‡
Benign
Epithelial
SNAIL	1.00^‡	0.26^∗			0.33^∗				0.37^∗									0.31^∗
GLI1	0.26^∗	1.00^‡	0.45^†			0.34^∗	0.30^∗		0.28^∗		0.30^∗
SMO		0.45^†	1.00^‡	0.57^†		0.53^†	0.70^‡		0.30^∗			0.37^∗	0.34^∗
SNAI3			0.57^†	1.00^‡		0.48^†	0.57^†		0.27^∗			0.45^†	0.67^‡	0.24^∗				0.40^†
SHH	0.33^∗				1.00^‡	0.36^∗	0.24^∗	0.28^∗
GLI3		0.34^∗	0.53^†	0.48^†	0.36^∗	1.00^‡	0.67^‡		0.39^∗			0.39^∗	0.44^†	0.25^∗		0.35^∗		0.37^∗
GLI2		0.30^∗	0.70^‡	0.57^†	0.24^∗	0.67^‡	1.00^‡		0.33^∗			0.30^∗	0.46^†			0.27^∗		0.34^∗
SUFU					0.28^∗			1.00^‡
Cyclin D1	0.37^∗	0.28^∗	0.30^∗	0.27^∗		0.39^∗	0.33^∗		1.00^‡			0.40^†		0.29^∗				0.33^∗
PTCH1										1.00^‡			0.29^∗					0.42^†
Stromal
GLI1		0.30^∗									1.00^‡	0.42^†		0.25^∗	0.38^∗	0.34^∗	0.24^∗
SMO			0.37^∗	0.45^†		0.39^∗	0.30^∗		0.40^†		0.42^†	1.00^‡	0.46^†	0.60^‡	0.59^†	0.33^∗		0.45^†
SNAI3			0.34^∗	0.67^‡		0.44^†	0.46^†			0.29^∗		0.46^†	1.00^‡			0.44^†		0.46^†
SHH				0.24^∗		0.25^∗			0.29^∗		0.25^∗	0.60^‡		1.00^‡	0.57^†			0.36^∗
GLI3											0.38^∗	0.59^†		0.57^†	1.00^‡	0.35^∗		0.36^∗
GLI2						0.35^∗	0.27^∗				0.34^∗	0.33^∗	0.44^†		0.35^∗	1.00^‡		0.35^∗
SUFU											0.24^∗						1.00^‡
PTCH1	0.31^∗			0.40^†		0.37^∗	0.34^∗		0.33^∗	0.42^†		0.45^†	0.46^†	0.36^∗	0.36^∗	0.35^∗		1.00^‡

Pearson correlation coefficients of statistically significant (P < 0.05) correlations are given. Empty cells indicate that there was no significant result.

GLI, glioma-associated oncogene; Hh, Hedgehog; PTCH, Patched; SHH, Sonic Hh; SMO, Smoothened; SNAI3, snail family transcriptional repressor 3; SNAIL, snail family transcriptional repressor 1; SUFU, suppressor of fused.

^∗

Weak correlation.

^†

Moderate correlation.

^‡

Strong correlation.