Table 1.
Summary of Histopathologic Findings in Borrelia burgdorferi Tick-Infected Rhesus Macaques
| Group | Age, y | Peripheral nerves | Heart/pericardium | Brain/leptomeninges | Urinary bladder | Skeletal muscle | Stifle joint |
|---|---|---|---|---|---|---|---|
| Untreated | |||||||
| IP55 | 3.73 | 3∗ (green)† | 0/0 | 0 | 2 | 0 | 0 |
| IP67 | 3.89 | NE (green)† | 0/0 | 0 | 0 | 0 | 0 |
| IN16 | 3.83 | 0 | 2/0 | 0 | 3 | 0 | 1 |
| IL75 | 4.06 | 3∗ | 0/0 | 0 | 2 (red)† | 0 | 0 |
| IN05 | 4.11 | 2∗ | 1/0 | 0 | 2 | 0 | 0 |
| Ratio (%) | NA | 3/4 (75) | 2/5 (40) | 0/0 (0) | 4/5 (80) | 0/5 (0) | 1/5 (20) |
| Treated | |||||||
| IH11 | 3.97 | 2∗ | 1/0 | 1 (green)† | 3 | 0 | 2 |
| IK66 | 3.92 | 1 | 1/0 | 0 | 2 | 2 (green and red)† | 0 |
| IK14 | 4.09 | 0 | 2/0 (red)† | 0 | 2 | 0 | 0 |
| IL09 | 4.07 | 0 | 0/0 | 0 | 2 | 0 | 1 (red)† |
| IH22 | 4.18 | 0 | 2/2 | 1 (green)† | 0 | 0 | 0 |
| Ratio (%) | NA | 2/5 (40) | 4/5 (80) | 2/5 (40) | 4/5 (80) | 1/5 (20) | 2/5 (40) |
| Controls | |||||||
| HT73 | 4.16 | 0 | 0 | 0 | 2 | 0 | NE |
| IK20 | 3.99 | 0 | 0 | 0 | NE | NE | NE |
| KB40 | 5.17 | 1 | 0 | 1 | 1 | 0 | 0 |
| IH80 | 7.59 | 0 | 3 (marked fibrosis) | 0 | 2 | 0 | 1 |
| Ratio (%) | NA | 1/4 (25) | 1/4 (25) | 1/4 (25) | 3/3 (100) | 0/3 (0) | 1/2 (50) |
NA, not applicable; NE, not examined.
∗
Multiple nerves affected simultaneously.
†
Positive by immunofluoresence. Red represents detection by anti–outer surface protein A monoclonal antibodies; green represents detection by rabbit anti-Borrelia polyclonal antibodies.