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. 2018 Mar;188(3):586–599. doi: 10.1016/j.ajpath.2017.10.023

Figure 3.

Figure 3

miR-31-3p regulates inflammatory gene expression in colonic epithelial cells. A and B: miR-31-3p down-regulation increases chemokine (C-C motif) ligand 2 (CCL2) (A) and IL-6 (B) mRNA expression in response to substance P (SP) stimulation. C and D: miR-31-3p overexpression decreases CCL2 (C) and IL-6 (D) mRNA expression in response to SP stimulation. E and F: miR-31-3p overexpression decreases CCL2 (E) and IL-6 (F) mRNA expression after incubation with a cytokine cocktail. G and H: miR-31-3p overexpression decreases IL-1B (G) and tumor necrosis factor (TNF)-α (H) mRNA expression in response to a cytokine cocktail. Data are expressed as means ± SD. n = 3.∗P < 0.05. As, antisense; con, control.