Table I.

Effect of DEPs on airway-specific, afferent nerve fibers in vivo in the guinea pig

	C-fiber (CV ≤1 m/s [n = 3])	Aδ-fiber (CV >1 m/s [n = 4])
DEP (10 μg/mL administered intratracheally)	7.33 ± 0.88*	1.6 ± 0.51
Acrolein (10 mmol/L, aerosol)	8.67 ± 1.20*	1.6 ± 0.68
Capsaicin (100 μmol/L, aerosol)	8.33 ± 0.33*	Capsaicin sensitive: 11.3 ± 4.05*	Capsaicin insensitive: 1.27 ± 0.37*

Peak action potential impulses (imp s⁻¹) induced by DEPs (10 μg/mL administered intratracheally), acrolein (10 mmol/L in saline, aerosolized for 60 seconds), or capsaicin (100 μmol/L in saline, aerosolized for 15 seconds) recorded from airway C-fiber or Aδ-fiber afferents are shown. Data are presented as means ± SEMs, and analyzed by using a paired t test, comparing responses (absolute values) after stimulus with baseline values immediately preceding the response. Asterisks indicate statistical significance, which was set at a P value of less than .05.