Expression of GRK6 was upregulated in CRC tissues. (A) Western blot analysis of eight representative paired samples of CRC tissues and PCHNTs. (B) Quantitative analysis of western blotting results of GRK6 expression in 19 CRC tissues and corresponding PCHNTs. (C) The expression levels of GRK6 mRNA in CRC tissues and PCHNTs were determined by reverse transcription-quantitative polymerase chain reaction and were normalized to the levels of GAPDH. ***P<0.05. CRC, colorectal carcinoma; GRK6, G protein-coupled receptor kinase 6; PCHNT, paracancerous histological normal tissue; T, tumor tissue; N, non-tumor tissue.