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. 2018 Feb 9;15(4):5865–5870. doi: 10.3892/ol.2018.8017

Figure 3.

Figure 3.

BANCR overexpression promotes cellular invasion and metastasis by inducing EMT in PTC. (A) The expression of N-cadherin and vimentin was upregulated, and the expression of E-cadherin was downregulated in BCPAP-BANCR cells compared with in BCPAP-NC cells. (B) Western blot analysis of the expression of E-cadherin, vimentin and N-cadherin in BCPAP-NC and BCPAP-BANCR cells. (C) Expression of E-cadherin, vimentin and N-cadherin in BCPAP-NC and BCPAP-BANCR cells as assessed using confocal microscopy. DAPI was used to stain the nucleus. Increased BANCR expression upregulated vimentin and downregulated E-cadherin in BCPAP-BANCR cells. (n=3; magnification, ×100). *P<0.05, **P<0.01, ***P<0.001 vs. BCPAP-NC cells. PTC, papillary thyroid carcinoma; BANCR, BRAF-activated non-protein-coding RNA; NC, negative control; E-cadherin, epithelial cadherin; N-cadherin, neuronal cadherin.