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. 2018 Jan 8;10(3):e7929. doi: 10.15252/emmm.201707929

Figure 6. Deconvolution of IRE1 signaling in GBM tumors.

Figure 6

  • A
    Schematic representation of the antagonistic XBP1s and RIDD signals in GBM tumors and their biological impact on tumor aggressiveness.
  • B, C
    Hierarchical clustering of GBM patients (TCGA cohort—microarray, B; TCGA cohort—RNAseq, C) based on XBP1s and RIDD scores (see Materials and Methods).
  • D, E
    Kaplan–Meier survival curves of XBP1+/RIDD− (red) and XBP1−/RIDD+ (blue) GBM patients of the TCGA microarray cohort (D), TCGA RNAseq cohort (E). Student's t‐test was used.
  • F, G
    Expression of monocyte (IBA1), angiogenesis (CD31), and migration/invasion (RHOA) markers mRNA in the four groups established in the two cohorts. Horizontal lines indicate median; box lines indicate first & third quartiles; whiskers indicate min & max. Student's t‐test was used.