Table III.
Univariate and multivariate analyses of risk factors associated with overall survival in patients treated with radical CRT.
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Test group | Reference group | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age (years) | ≤65 | >65 | 0.992 | 0.974–1.010 | 0.375 | – | – | – |
| Sex | Female | Male | 0.478 | 0.246–0.929 | 0.029a | 0.449 | 0.229–0.880 | 0.020a |
| Pathological type | SCC | Others | 1.824 | 0.573–5.804 | 0.309 | – | – | – |
| Tumor location | Lower | Upper/middle | 0.802 | 0.465–1.384 | 0.428 | – | – | – |
| Tumor length (cm) | >7 | ≤5/5–7 | 1.236 | 0.771–1.982 | 0.379 | – | – | – |
| T-classification | T3-4 | T1-2 | 2.115 | 1.015–4.405 | 0.045a | 0.833 | 0.309–2.247 | 0.718 |
| N-classification | N+ | N0 | 1.354 | 0.852–2.152 | 0.200 | – | – | – |
| Clinical stage | III | I/II | 2.326 | 1.341–4.035 | 0.003a | 2.471 | 1.171–5.212 | 0.018a |
| Concurrent chemoradiation | Performed | Not performed | 0.602 | 0.383–0.948 | 0.028a | 0.590 | 0.368–0.945 | 0.028a |
| PD-L1 expression | Positive | Negative | 0.552 | 0.348–0.877 | 0.012a | 0.600 | 0.372–0.965 | 0.035a |
| NLR (mean) | >2.64 | ≤2.64 | 1.310 | 0.796–2.156 | 0.288 | – | – | – |
| PLR (mean) | >138.87 | ≤138.87 | 1.066 | 0.650–1.749 | 0.800 | – | – | – |
| LMR (mean) | >4.62 | ≤4.62 | 0.687 | 0.420–1.123 | 0.134 | – | – | – |
a
Statistically significant (P<0.05). Only covariates with P<0.1 in the univariate analysis were considered in the multivariate analysis. HR, hazard ratio; CI, confidence interval; T-, tumor; N-, node; PD-L1, programmed death ligand 1; SCC, squamous cell carcinoma; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-leukocyte ratio; LMR, lymphocyte-to-monocyte ratio.