Table II.

Expression and clinical significance of IL-37 in human disorders.

Author	Year	Disease	No. of samples	Methods	Expression level	Association	(Refs.)
Liu et al	2014	Children with allergic rhinitis	40	ELISA	Decreased	The efficacy of intranasal steroid therapy	(14)
Li et al	2014	Graves' disease	40	RT-PCR and ELISA	Increased	TNF-a, IL-6, IL-17 and disease activity	(13)
Li et al	2014	Inflammatory bowel disease	27	ELISA	Decreased	UC activity	(28)
Højen et al	2015	Chronic HIV-1-infected individuals	60	Quantitative RT-PCR	Increased	The size of the total viral HIV-1 reservoir	(56)
Wan et al	2014	Intervertebral disc degeneration	14	RT-PCR and western blotting	Decreased	Disease aggravation	(57)
Günaltay et al	2014	Microscopic and ulcerative colitis	31	Quantitative RT-PCR	Decreased	Possible UC remission	(58)
Chen et al	2015	Ankylosing spondylitis	46	RT-PCR and ELISA	Increased	Disease activity	(59)
Ye et al	2014	Systemic lupus erythematosus	66	RT-PCR and ELISA	Increased	Disease activity	(60)
Ji et al	2014	Acute coronary syndrome	257	ELISA	Increased	The onset of ACS	(61)
Wang et al	2015	Myocardial infarction	56	Immunoblotting	Decreased	Possible leukocytic inflammation	(62)
Yu et al	2016	Arterial calcification	125	Immunohistochemistry and ELISA	Increased	The onset of arterial calcification	(63)
Zhao et al	2014	Hepatocellular carcinoma	163	Immunohistochemical staining	Decreased	Tumor size, OS, DFS, the density of tumor-infiltrating NK cells	(64)
Ge et al	2016	Non-small cell lung cancer	182	Immunohistochemical staining and RT-PCR	Decreased	Tumor angiogenesis	(65)

RT-PCR, reverse transcription polymerase chain reaction; OS, overall survival; DFS, disease-free survival; NK cells, natural killer cells; TNFα, tumor necrosis factor α; IL, interleukin; HIV, human immunodeficiency virus; ACS, acute coronary syndrome; UC, ulcerative colitis.