Table I.
Correlation between clinicopathological parameters and RAB1A expression levels/human epidermal growth factor receptor 2 amplification in 280 patients with gastric cancer.
| HER-2 amplification | RAB1A expression | ||||||
|---|---|---|---|---|---|---|---|
| Clinicopathologic characteristics | n | Positive | Negative | P-value | Positive | Negative | P-value |
| Age (years) | 0.580 | 0.157 | |||||
| ≥60 | 191 | 26 (72.2) | 165 (67.6) | 124 (65.3) | 67 (74.4) | ||
| <60 | 89 | 10 (27.8) | 79 (32.4) | 66 (34.7) | 23 (25.6) | ||
| Sex | 0.290 | 0.329 | |||||
| Female | 108 | 11 (30.6) | 97 (39.8) | 77 (40.5) | 31 (34.4) | ||
| Male | 172 | 25 (69.4) | 147 (60.2) | 113 (59.5) | 59 (65.6) | ||
| Lauren | <0.001a | 0.157 | |||||
| Intestinal | 90 | 27 (75.0) | 63 (25.8) | 60 (31.6) | 30 (33.3) | ||
| Diffuse | 114 | 6 (16.7) | 108 (44.3) | 72 (37.9) | 42 (46.7) | ||
| Mixed | 76 | 3 (8.3) | 73 (29.9) | 58 (30.5) | 18 (20.0) | ||
| Tumor size (cm) | <0.001a | <0.001a | |||||
| ≥5 | 93 | 25 (69.4) | 68 (27.9) | 75 (39.5) | 18 (20.0) | ||
| <5 | 187 | 11 (30.6) | 176 (72.1) | 115 (60.5) | 72 (80.0) | ||
| Lymph node invasion | <0.001a | <0.001a | |||||
| Positive | 81 | 19 (52.8) | 62 (25.4) | 69 (36.3) | 12 (13.3) | ||
| Negative | 199 | 17 (47.2) | 182 (74.6) | 121 (63.7) | 78 (86.7) | ||
| TNM stage | 0.066 | <0.001a | |||||
| I–II | 171 | 27 (75.0) | 144 (59.0) | 137 (72.1) | 34 (37.8) | ||
| III–IV | 109 | 9 (25.0) | 100 (41.0) | 53 (27.9) | 56 (62.2) | ||
| WHO Classification | 0.265 | 0.040a | |||||
| High | 39 | 8 (22.2) | 31 (12.7) | 24 (12.6) | 15 (16.7) | ||
| Medium | 152 | 19 (52.8) | 133 (54.5) | 113 (59.5) | 39 (43.3) | ||
| Low | 89 | 9 (25.0) | 80 (32.8) | 53 (27.9) | 36 (40.0) | ||
| Recurrence | <0.216 | <0.001a | |||||
| Yes | 70 | 12 (33.3) | 58 (23.8) | 60 (31.6) | 10 (11.1) | ||
| No | 210 | 24 (66.7) | 186 (76.2) | 130 (68.4) | 80 (88.9) | ||
| Helicobacter pylori infection | 0.742 | 0.556 | |||||
| Yes | 231 | 29 (80.6) | 202 (82.8) | 155 (81.6) | 76 (84.4) | ||
| No | 49 | 7 (19.4) | 42 (17.2) | 35 (18.4) | 14 (15.6) | ||
a
P<0.05, Chi-square test and Fisher's exact test. HER-2, human epidermal growth factor receptor 2; TNM, tumour, node and metastasis; WHO, World Health Organisation.