Table II.
Univariate and multivariate analyses of various potential prognostic factors in 280 patients with gastric cancer.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Factor | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age | 1.152 (0.732–1.811) | 0.541 | – | – |
| Sex | 1.096 (0.730–1.645) | 0.659 | – | – |
| Tumor size | 1.214 (0.800–1.843) | 0.361 | – | – |
| TNM stage | 0.991 (0.663–1.482) | 0.966 | – | – |
| Helicobacter pylori infection | 1.162 (0.681–1.983) | 0.582 | – | – |
| Lauren type | 0.505 (0.383–0.667) | <0.001a | 0.679 (0.445–1.036) | 0.072 |
| Lymph node invasion | 3.184 (2.141–4.736) | <0.001a | 0.743 (0.422–1.307) | 0.302 |
| RAB1A overexpression | 1.938 (1.277–2.943) | 0.002a | 0.932 (0.619–1.442) | 0.669 |
| Recurrence | 2.567 (1.715–3.841) | <0.001a | 0.787 (0.425–1.454) | 0.444 |
| HER-2 amplification | 9.241 (5.973–14.296) | <0.001a | 1.291 (1.081–2.365) | 0.253 |
| WHO classification | 1.687 (1.261–2.258) | 0.001a | 1.400 (0.813–2.413) | 0.225 |
| RAB1A/HER-2 co-expression | 9.241 (5.973–14.296) | <0.001a | 6.662 (3.448–12.871) | <0.001a |
a
P<0.05. HR, hazard ratio; CI, confidence interval; WHO, World Health Organisation; TNM, tumor, node, metastasis; HER-2, human epidermal growth factor receptor 2.