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Treatment with curcumin significantly suppresses proliferation of U-2 OS cells, and the effect of curcumin-mediated suppression decreases following knockdown of inositol 1,4,5-triphosphate receptor type 1. *P<0.05, compared with negative control cells and control cells; #P<0.01, compared with negative and curcumin-treated cells. si, small interfering; con, control.
