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Treatment with curcumin significantly promotes apoptosis of U-2 OS cells, while the apoptotic rate of U-2 OS cells transfected with inositol 1,4,5-triphosphate receptor type 1 siRNA sequences were significantly decreased. *P<0.05, compared with negative control cells and control cells; #P<0.05, compared with negative and curcumin-treated cells. si, small interfering; con, control.
