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Treatment with curcumin significantly inhibits cell migration, while ITPR1 interference promotes migration of U-2 OS cells (magnification, ×200). *P<0.01, compared with negative control cells and control cells (Note: for siRNA treated cells at 12 h, the *P<0.01 is compared with control cells); #P<0.05, compared with negative and curcumin-treated cells. si, small interfering; con, control. ITPR1, inositol 1,4,5-triphosphate receptor type 1.
