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Treatment with curcumin significantly inhibits invasion of U-2 OS cells, and inositol 1,4,5-triphosphate receptor type 1 interference relieves the inhibitory effect of curcumin on cell invasion (magnification, ×200). *P<0.05 compared with negative control cells and control cells; #P<0.05 compared with negative and curcumin-treated cells. si, small interfering; con, control.
