Table I.

Association between CTLA-4 expression and clinicopathological characteristics.

		Tumor CTLA-4			Interstitial CTLA-4
Clinicopathological characteristics	n	(+)	(−)	P-value	(+)	(−)	P-value
Age (years)				0.099			0.845
<35	8	6	2		5	3
≥35	94	36	58		49	45
Menopausal status				0.868			0.560
Premenopausal	52	21	31		29	23
Postmenopausal	50	21	29		25	25
Histological grade				0.422			0.148
I	16	6	10		11	5
II	58	27	31		32	26
III	28	9	19		11	17
Tumor size (cm)				0.636			0.243
≤2	49	19	30		23	26
>2	53	23	30		31	22
Lymph node				0.332			0.161
Negative	52	19	33		24	28
Positive	50	23	27		30	20
Tumor stage				0.298			0.114
I	29	10	19		11	18
II	47	18	29		26	21
III	26	14	12		17	9
Ki-67				0.884			0.376
<14	9	3	6		3	6
≥14	93	39	54		51	42

CTLA-4, cytotoxic T lymphocyte-associated antigen 4.