Figure 2.

miR-21-5p induces the metastatic phenotype of the CC CaSki cell line. (A) miR-21-5p expression in CaSki cells transfected with miR-21-5p mimic/inhibitor. (B) miR-21-5p induces the proliferation of CaSki cells. (C) miR-21-5p inhibits CaSki cell apoptosis. (D) miR-21-5p induces the migration of CaSki cells. (E) miR-21-5p induces the invasion of CaSki cells. The expression of miR-21-5p in CC cells was determined using quantitative polymerase chain reaction, while Transwell chambers were used for determining the migration and invasion abilities of CaSki cells. Statistical analysis was performed using one-way analysis of variance. Error bars represent the standard deviation. **P<0.01 and ***P<0.001 vs. untransfected. ns, non-significant; miR, microRNA; CC, cervical cancer; NC, negative control; ctrl, control. Figures were obtained at ×100 magnification of under a white light microscope following crystal violet staining.