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. 2018 Mar 6;18:259. doi: 10.1186/s12885-018-4104-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow chart of signature identification and validation strategy. Abbreviations: BJ cohort, patients from Peking University People’s Hospital; CQ cohort, patients from Southwest Hospital of Chongqing; ADC, adenocarcinoma; SCC, squamous cell carcinoma; IHC, immunohistochemistry; EGFR-TKI, epidermal growth factor receptor tyrosine kinase inhibitor