Table 5.
Quantitative MRI results: change from screening to month 12 in tibial cartilage volume and bone area
| Placebo (n = 4) |
PRG 3.9M (n = 8) |
PRG 6.7M (n = 8) |
Placebo – PRG 3.9M | Placebo – PRG 6.7M | |
|---|---|---|---|---|---|
| Lateral tibial cartilage volume, mm3 | − 95.4 (− 172.6, − 18.2) p = 0.019 |
11.1 (− 37.1, 59.3) p = 0.628 |
− 78.0 (− 125.9, − 30.1) p = 0.004 |
106.5 (13.6, 199.4) p = 0.028 |
17.4 (− 74.6, 109.4) p = 0.690 |
| Lateral tibial cartilage volume, % change | − 5.0 (− 8.8, − 1.3) p = 0.012 |
0.4 (− 2.0, 2.7) p = 0.730 |
− 3.5 (− 5.8, − 1.2) p = 0.006 |
5.4 (0.9, 9.9) p = 0.022 |
1.5 (− 2.9, 6.0) p = 0.475 |
| Medial tibial cartilage volume, mm3 | − 15.4 (− 166.8, − 136.0) p = 0.830 |
− 30.3 (− 141.2, 80.5) p = 0.567 |
− 73.8 (− 186.1, 38.6) p = 0.181 |
− 14.9 (− 203.2, 173.4) p = 0.868 |
− 58.3 (− 250.6, 133.9) p = 0.526 |
| Medial tibial cartilage volume, % change | − 1.7 (− 8.8, 5.3) p = 0.607 |
− 1.5 (− 6.7, 3.6) p = 0.532 |
− 3.5 (− 8.7, 1.8) p = 0.178 |
0.2 (− 8.6, 9.0) p = 0.964 |
− 1.7 (− 10.7, 7.2) p = 0.685 |
| Lateral tibial bone area, mm2 | − 10.0 (− 70.9, 50.9) p = 0.730 |
− 8.5 (− 54.4, 37.4) p = 0.698 |
25.6 (− 71.6, 20.4) p = 0.253 |
1.5 (− 74.7, 77.7) p = 0.967 |
− 15.6 (− 92.1, 60.9) p = 0.669 |
| Lateral tibial bone area, % change | − 0.2 (− 4.0, 3.6) p = 0.906 |
− 0.2 (− 3.1, 2.7) p = 0.888 |
− 2.0 (− 4.9, 0.9) p = 0.158 |
0.0 (− 4.8, 4.8) p = 0.993 |
− 1.8 (− 6.6, 3.0) p = 0.436 |
| Medial tibial bone area, mm2 | 30.4 (− 41.6, 102.4) p = 0.381 |
50.3 (1.1, 99.6) p = 0.046 |
− 17.0 (− 68.1, 34.1) p = 0.487 |
20.0 (− 68.6, 108.5) p = 0.636 |
− 47.4 (− 140.4, 45.6) p = 0.293 |
| Medial tibial bone area, % change | 1.4 (− 1.6, 4.3) p = 0.336 |
2.0 (− 0.0, 4.0) p = 0.051 |
− 1.0 (− 3.1, 1.1) p = 0.326 |
0.6 (− 3.0, 4.3) p = 0.712 |
− 2.4 (− 6.2, 1.4) p = 0.205 |
Increase in cartilage volume = improvement; Increase in bone area = worsening