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. 2018 Mar 7;15:72. doi: 10.1186/s12974-018-1105-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Antigen-specific response in EAE is mediated by STAT protein phosphorylation. Splenocytes from EAE and control mice were stimulated with MOG_35–55 peptide for 24 h and levels of p-p38MAPK, p-Erk1/2, p-STAT1, p-STAT3, p-STAT4, p-STAT5, and p-STAT6 were evaluated. Boxplots show the fold change in protein phosphorylation compared to unstimulated cells. MOG_35–55 stimulation induced phosphorylation of STAT1 in all cell types, p38MAPK in B cells and CD4 T cells, STAT5 in CD4 and CD8 T cells, and STAT4 in CD4 T cells of EAE mice but not control mice. Statistical differences were calculated using an unpaired t test