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. 2018 Mar 6;15:69. doi: 10.1186/s12974-018-1092-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Neuroinflammation, BBB disruption, and CMH development. Significantly higher Iba-1-positive immunoreactivity with aging (a), and GFAP- (b) and IgG- (c) positive immunoreactivity in LPS-treated aged mice compared with LPS-treated young mice. PB- and H&E-positive CMH numbers are significantly correlated with Iba-1 positive immunoreactivity in aged mice (d, e). Representative images of Iba-1, GFAP, and IgG immunohistochemistry (f). Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post-test or Kruskal-Wallis test with Dunn’s post-test and Pearson correlation; *p < 0.05, **p < 0.01, and ****p < 0.0001