Figure 3. Associations of [¹¹C](R)-PK11195 binding to disability and diffusion tensor imaging (DTI) changes in patients with MS.

Region of interest–specific binding of [¹¹C](R)-PK11195 measured as the distribution volume ratio (DVR) in the normal-appearing white matter (NAWM) plotted with (A) Expanded Disability Status Scale (EDSS), (B) MS severity score (MSSS), (C) mean fractional anisotropy (FA) in the NAWM, and (D) the DVR in the thalami plotted with mean FA in the NAWM in the pooled MS patient group. The correlations are visualized with linear regression lines corresponding to the results from repeated-measures analysis of covariance (rm ANCOVA) reported in tables e-1 and e-3 (links.lww.com/NXI/A37). SPMS = secondary progressive MS; RRMS = relapsing-remitting MS.