Table II.
Regulatory effects of GIPS and Tα1 on interleukins, interferons and MCP-1 in spleen of CTX-induced immunosuppressed mice.
| GIPS (g/kg) | Tα1 (mg/kg) | |||||
|---|---|---|---|---|---|---|
| Protein | CTRL | Model | 0.1 | 0.3 | 0.9 | 0.16 |
| IL-2 (pg/mg) | 21.2±1.0 | 6.7±0.8b | 9.0±0.4 | 9.5±1.0 | 19.5±4.0d | 12.0±0.7c |
| IL-3 (pg/mg) | 6.4±0.37 | 3.8±0.4a | 4.7±0.5 | 5.2±0.4 | 7.4±1.3d | 6.0±0.7c |
| IL-6 (pg/mg) | 9.7±0.7 | 3.6±0.5b | 5.7±0.4 | 6.6±0.6c | 8.5±1.1e | 7.2±0.7d |
| IFN-α (pg/mg) | 2.6±0.2 | 1.6±0.1a | 2.4±0.1 | 2.6±0.3 | 2.7±0.1c | 3.6±0.5d |
| IFN-γ (pg/mg) | 15.4±0.8 | 7.9±0.6b | 9.5±0.8 | 9.2±0.5 | 11.9±1.3c | 12.4±1.2d |
| MCP-1 (pg/mg) | 1.3±0.1 | 0.9±0.1b | 1.2±0.1d | 1.5±0.1e | 1.6±0.1e | 1.3±0.1d |
Data were expressed as means ± SEM (n=12).
a
P<0.05
b
P<0.001 vs. control group
c
P<0.05
d
P<0.01
e
P<0.001 vs. model group. CTX, Cyclophosphamide; GIPS, G. incarnatum polysaccharides; Tα1, Thymosin α1; CTRL, control; IL, interleukin; IFN, interferon; MCP, monocyte chemotactic protein.