Figure 2.

Assay results for gentamicin exposure plus a compound dose of 1,000 μM.

The percent of hair cells (HCs) initially present in micro-explants exposed to gentamicin alone has been subtracted from that for micro-explants exposed to the compound plus gentamicin. Because antioxidants showed peak protection on different days after the initiation of gentamicin exposure, the highest difference observed either on Day 1, Day 2 or Day 3 of culture is presented. Compounds that proved to provide statistically significant protection after validation are indicated by an asterisk. Most of these compounds showed a protective effect above 25% at 1,000 μM compound concentration. A few (B7 and F7) showed protective effects at lower compound dosages but not at the 1,000 μM concentration illustrated here. Compound identities can be found in the Supplementary Table 1 of Noack et al. (2017). Data were evaluated by analysis of variance and Fisher's post hoc test with Bonferonni correction for multiple conditions. *P < 0.05.